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Soto's Syndrome

What is Soto's Syndrome?

Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. Children with Soto's syndrome tend to be large at birth and are often taller, heavier, and have larger heads than is normal for their age.

Soto's syndrome is not a life-threatening disorder. Individuals with Soto's syndrome may have a normal life expectancy. The initial abnormalities of Soto's syndrome usually resolve and the growth rate may slow to normal at four or five years of age. Developmental delays may improve in the school-age years.

Soto's syndrome is also called cerebral gigantism.

Symptoms of Soto's Syndrome

Common symptoms of Soto's Syndrome are:

  • Mild mental retardation
  • Delayed motor development
  • Delayed cognitive development
  • Delayed social development
  • Hypotonia
  • Speech impairment
  • An abnormally increased distance between the eyes
  • Downslanting eyes
  • Tallness
  • Unusually large body
    • large head
    • large hands
    • large feet
  • Protrusive forehead
  • Hypertelorism
  • Clumsiness
  • Awkward gait
  • Unusual Aggressiveness
  • Irritability

What causes Soto's Syndrome?

Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported.

Can Soto's Syndrome be treated?

Soto's syndrome cannot be cured. Treatments are focused on relieving the severity of the symptoms.

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